Healing the Human Microbiome

People modernized cultures are facing a health catastrophe due to the collapse of microbial diversity in intestinal microbiome. There is increasing evidence that autoimmune diseases, including allergies, asthma, inflammatory bowel disorders, diabetes, etc ... may be associated with changes that occur in the intestinal microbioma. See recent generations outbreaks of these disorders. An argument Blazer Martin in his book "Microbes Missing" is that at the root of this crisis is that we are losing species diversity in our gut microbiome.

 Indeed, since Louis Pasteur's experiments supported the germ theory of people made war on germs. At first, it was thanks to applications of antimicrobial surface to kill microbes to prevent its spread; later (1930) sulfonamides have been developed to kill bacteria in the human body. In the 1940s, penicillin was developed to remove bacteria, and since then, antibiotics were the first weapons used by people to kill bacteria in the human body.

Most children born in the years following the development of antibiotics were provided series after series of antibiotics to control pain throat of childhood ear infections and various diseases of childhood. With each round of antibiotic treatment of bacterial diversity in the gut microbiome is lost. The loss of diversity in the human gut microbiome should be of no consequence if human intestinal functions as a dietary digestive organ. It now appears that this view of the human gut is incorrect or only partially correct. In fact, we now have evidence that the human intestine, the body's largest organ, can be considered a "symbiotic organ",

where the symbiosis with microorganisms is critical to its operation. Organ function symbio intestine digest food, provide unique nutrients vitamins, phytochemicals suppress detoxify pathogen virulence, modulate nervous system and equally important is its function to boot immune to the constant exposure to potential pathogens, keeping the immune system focused on microbes rather than the body itself. The symbiotic gut human body is actually a complex organ with multiple functions that affect the body in many ways, and not at all simple digestive tract to first imagine.

What the consequences of the loss of microbial diversity in the gut symbiotic organ? Regarding the immune response, loss of microbial diversity means that the body is prepared with a full complement of antigens gut microbes rather than focusing to maintain the immune response in the gut microbes Symbio-body registration, body develops autoimmune diseases,

allergies, asthma, Crohn's disease, etc ... The loss of microbial diversity also means that potential pathogens such as Clostridium difficile inhabiting the intestine can encourage disease. It seems clear that the various intestinal microbial communities have the ability to suppress virulence of potential pathogens in the gut. Precisely how microbes other microbes suppress virulence is unclear,

although some evidence for organic acids (eg, lactic acid, butyric acid, propionic acid) as suppressors likely virulence in the gut. Alterations in the composition of organic acids are often seen along the cases of intestinal inflammation in irritable bowel disorder (IBD). Butyric acid has been shown to suppress inflammation in acute outbreaks, and butyric acid producing bacteria are being considered as potential probiotics to control IBD and similar disorders. As a supplier of vitamins intestinal bacteria appear to be the main source of biotin and vitamin K, both essential nutrients in our body.

Where does gut microbiome? It is generally believed that humans inherit our microbiomes of our mothers. This is only partially true, but we know we can restore microbiome once damaged grafts and fecal specific probiotic microbes. It is also true that plants contain large populations of microbes on their surfaces (as epiphytes) and incorporated into their tissues (as endophytes). Some microbes plant are identical to those found in human intestinal communities. Endophytes and epiphytes microbes colonize all parts of the plant leaves,

stems, flowers and seeds, but more diverse communities are in the roots of plants. The root of the plant is essentially another body symbio the combination of microbes in a narrow zone (rhizosphere) around the roots in the process of absorption of nutrients from the soil. The root of the plant is equivalent to bowel function in terms of narrow absorption and partnership with a diverse community of microbes. A large part of plant foods for most people consume in our food crops are sweet potato roots, carrots, turnips, radishes, cassava, etc

... A variety of microbes can enter our gut microbiome in these plant foods, especially deep crops. However, modern humans cook most of our plants and processed foods are sterilized largely untapped potential residents microbiome. Because of this, food processing plants our consumption of microbes from plants is extremely limited. Only very strong Endopore leaders (as Bacillus or Clostridium) that can survive the cooking process or sterilization could enter our gut microbiome.

How can we heal the human microbiome? The solution for humanity is radically changing what we eat and how we prepare for consumption. Whenever possible, we should consume plant foods (leaves, flowers, fruits, seeds, roots, tubers) retain diverse populations and unpeeled raw microbes in them and live within them. We consume organically grown plants to maximize microbial diversity.

We have to change not only what we eat, but also what we feed our babies. Baby food now come perfectly may have to be based on fresh plants with intact bacteria or microbes but preserved lyophilised sterile aliquots for "strengthening the microbiome baby food. Currently, we also depend on cooking plants to soften and break down toxins in a future of new varieties chosen for their first major wholesomeness and several healthy microbial populations could develop crops.

The use of these new "probiotic cultures" could make it more convenient for people redevelop and maintain healthy microbiome. The great battle our microbes will have to end. Once we bought our gut microbiome our various organs Symbio-guts start operating properly again and epidemics of allergy, asthma, intestinal disorders and other autoimmune problems may simply disappear.

James F. White, Jr., Department of Plant Biology, Rutgers University, New Brunswick, NJ; 04/06/2015